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This involves removal and addition of chemicals, after glomerular filtrate leaves the Bowman's capsule and enters the renal tubule.

The Renal tubule is very long, which increases its absorptive surface area.

The second stage of urine formation is tubular reabsorption and secretion.Some substances are retained in the bloodstream because they are bound to plasma proteins that cannot get through the membrane.For example, most calcium, iron, and thyroid hormone in the blood are bound to plasma proteins that retard their filtration by the kidneys.Urine formation is a very sophisticated process that takes place in the kidneys.This important process provides a mechanism for the body to get rid of metabolic wastes and toxins, which can be deadly if allowed to accumulate in the body.

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